Endocrine Abstracts

Introduction: Congenital dystrophic epidermolysis bullosa (CDEB) is a rare genetic multisystem disease. Life expectancy of the patients has increased and the prevention of the delayed complications including osteoporosis has become relevant.Aim of the study: To study vitamin D status and phosphorus-calcium metabolism in the children with CDEB.Methods and materials: The study included 32 patients with CDEB, aged from 7 months to 18 ...

Introduction: Malnutrition, deficiency of micro- and macronutrients, including calcium and vitamin D are typical for children with dystrophic form of congenital epidermolysis bullosa (DEB). Thereby, there is a slowdown in osteogenesis and in stimulation of osteoclast activity, bone tissue resorption, which leads to increased bone fragility and low-traumatic fractures.Aim of the study: To evaluate markers of bone tissue metabolism and phosphorus-calcium m...